![]() ![]() Using venography as the gold standard, US for proximal DVT had a pooled sensitivity of 59% (95% confidence interval (CI) = 51%–66%) and a pooled specificity of 98% (95% CI = 97%–98%), US for distal DVT had a poor sensitivity of 43% (95% CI = 38%–48%) and a pooled specificity of 95% (95% CI = 94%–96%), US for whole-leg DVT had a pooled sensitivity of 59% (95% CI = 54%–64%) and a pooled specificity of 95% (95% CI = 94%–96%), US for post-major orthopedic surgery patients had a pooled sensitivity of 52% (95% CI = 49%–55%), and US for other types of patients had a pooled sensitivity of 58% (95% CI = 43%–72%). The meta-analysis included 26 articles containing 41 individual studies with a total of 3951 patients without symptoms of DVT. The study quality and the risk of bias were evaluated using QUADAS-2, with heterogeneity was assessed and quantified by the Q score and I 2 statistics, respectively. There were 4 different classes of subgroup analysis-the class of patients stratified by location of US exam (proximal, distal, whole leg), the class stratified by technique (color/doppler, compression, both modalities), the class stratified by kind of surgery (orthopedic, otherwise hospitalized) and the class stratified by era of publishing (1980s, 1990s, 2000s). A meta-analysis was performed using Meta-DiSc (version 1.4), providing the pooled sensitivity, specificity, positive (LR+) and negative (LR–) likelihood ratios of the detection accuracy of US. Full-text reports on prospective diagnostic studies involve the detection of lower-limb proximal and distal DVT in patients without symptoms of DVT using US and venography. The research team performed a systematic search in PubMed, Ovid, Cochrane, and Web of Science without language or date restrictions. To assess whether the ultrasound (US) is a reliable approach in detecting lower-limb deep-vein thrombosis (DVT) in patients without symptoms of DVT. The work cannot be changed in any way or used commercially without permission from the journal. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The authors have no conflicts of interests to disclose. The rate of missed diagnosis of lower-limb DVT by ultrasound amounts to 50% or so in patients without symptoms of DVT. ![]() How to cite this article: Zhang Y, Xia H, Wang Y, Chen L, Li S, Hussein IA, Wu Y, Shang Y, Yao S, Du R. ∗Correspondence: You Shang, Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei China (e-mail: ) Yan Wu, Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (e-mail: ).Ībbreviations: CI = confidence interval, DVT = deep-vein thrombosis, LR– = negative likelihood, LR+ = positive likelihood, MOOSE = Meta-analysis of Observational Studies in Epidemiology, PRISMA = Preferred Reporting Items for Systematic reviews and Meta-Analyses, US = Ultrasound. This test takes from 10 to 30 minutes.BDepartment of Critical Care Medicine, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,ĬDepartment of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaĭUniversity of New Mexico Comprehensive Cancer, Albuquerque, NM, USA. VENOUS DOPPLER: This test is used to check for blood clots in the legs or arms. This test can take anywhere from 30 to 90 minutes. Both limbs will be examined as well as the major arteries in the abdomen. This test will take approximately ½ hrĪRTERIAL DOPPLER OF THE EXTREMITIES (Legs or Arms): This is used to evaluate the blood flow to the extremities from the heart. They supply blood from the heart to the face and brain. You will hear the sound of the blood flow at various times during the test.ĬAROTID DOPPLER: The carotid arteries are the main vessels running up each side of the neck. This allows the technologist to observe and measure the flow of blood in your vessels. A form of ultrasound known as Doppler is used. Vascular ultrasound is used to examine the blood flow in arteries and veins. ![]()
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